The development of the concept of superbase, the systematic use of superbasic catalysts and reagents in the chemistry of acetylene, heterocyclic compounds, organic compounds of phosphorus, sulfur, selenium, tellurium, new general reactions and methods for the synthesis of organic and organoelemental compounds Trofimova-Gusarova - synthesis of organophosphorus compounds from elemental phosphorus).
Technologically oriented methods for the synthesis of a number of polyfunctional monomers, intermediates and building blocks for organic synthesis, organic sulfur polymers, epoxy resins, crosslinking agents, ion exchangers, extractants, sorbents, surfactants, corrosion inhibitors, fuel additives, electrically conductive, redox and photosensitive polymers, organic electrolytes, pharmaceuticals, fragrances, aromatic additives, pesticides.